Pair Name	Curcumin, Anti-PD-1 antibody
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Immune evasion
Gene Regulation	Down-regulation	Expression	EP300	hsa2033
	Down-regulation	Activity	SMAD2/3	KEGG ID N.A.
	Down-regulation	Expression	TGFB1	hsa7040
In Vitro Model	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0326
In Vivo Model	Hep3B cells in the logarithmic growth phase were suspended in 50% Matrigel (BD Biosciences) and adjusted to a density of 2×10⁶ cells/mL, and 0.2 mL of single-cell suspension was subcutaneously injected into the left axilla of each mouse.
Result	Synergistic efficacy of curcumin and anti-programmed cell death-1 in hepatocellular carcinoma